Corvo Attano returns from searching the Isles for aid to cure the rat plague that is constantly spreading. After returning, he faces a terrible "welcome back" gift...the fair Empress Jessamine Kaldwin gets assassinated by Daud's men. Lord Regent (Spymaster) and High Overseer Campbell frame Corvo Attano for the assassination, so he is imprisoned in Coldridge for 6 months. With the help of the Loyalists, Corvo manages to escape into the Hounds Pit Pub, where his journey begins, everyone knows...where his journey ends, nobody knows.